5. Impact of concentrating cerebrospinal fluid on Xpert Ultra and Xpert MTB/RIF sensitivity and specificity.

Covariate (number of studies, participants)	Pooled sensitivity (95% CrI)	Pooled specificity (95% CrI)
Concentration step, Xpert Ultra
Concentrated specimen (3, 421)	90.5% (76.7 to 97.0)	91.9% (84.5 to 96.1)
Unconcentrated specimen (3, 54)	88.4% (67.8 to 97.5)	88.6% (58.4 to 99.0)
Difference (concentrated minus unconcentrated)	2.6% (−13.9 to 24.1)	3.4% (−9.5 to 32.8)
Probability (concentrated minus unconcentrated)	0.630	0.653
Concentration step, Xpert MTB/RIF
Concentrated specimen (14, 2279)	77.6% (67.2 to 85.9)	97.4% (96.1 to 98.4)
Unconcentrated specimen (17, 1123)	59.4% (48.3 to 70.5)	96.8% (94.0 to 98.7)
Difference (concentrated minus unconcentrated)	18.4% (2.8 to 32.1)	0.6% (−1.7 to 3.6)
Probability (concentrated minus unconcentrated)	0.989	0.696

Abbreviations: Crl: credible interval.