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. 2014 Oct 28;2014(10):CD007482. doi: 10.1002/14651858.CD007482.pub3

Gerstner 1980.

Methods Randomized trial; 2 parallel groups.
Unit of randomization: individual.
Participants Dates of data collection: August 1979 and April 1980.
Setting: Universitats‐Frauenklinik Wien, Austria.
Inclusion criteria: women undergoing CS. N = 103.
Interventions Intervention:
  • metronidazole 500 mg IV before induction of anesthesia and 12 and 24 hrs post‐operatively, then rectal suppository x 4 days;

  • N = 53.


Comparison: no treatment:
  • no treatment;

  • N = 50.

Outcomes Fever (> 38oC on 2 subsequent days); wound infection; endometritis; additional use of antibiotics (treatment 13/53 vs control 22/50); maternal hospital days.
Notes Full translation pending.
Class of antibiotic: nitroimidazole (metronidazole).
Subgroups:
  • type of CS unclear;

  • before cord clamping.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "...randomized...".
Comment: no description of sequence generation process and no further details provided in translation.
Allocation concealment (selection bias) Unclear risk Comment: no information provided.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: no losses or exclusions were reported; appears to be an ITT analysis.
Selective reporting (reporting bias) Unclear risk Comment: insufficient information to judge.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: no blinding; not placebo‐controlled.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: probably outcome assessment was not blinded.
Other bias Low risk Comment: no other sources of bias identified.