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. 2014 Oct 28;2014(10):CD007482. doi: 10.1002/14651858.CD007482.pub3

Gummerus 1984.

Methods 'Randomly divided' (no details provided); placebo‐controlled.
Participants Dates of data collection: December 1981 to August 1982.
Setting: School of Midwifery, Helsinki, Finland.
Inclusion criteria: women undergoing CS (average duration of labor 8 hrs 45 min; average duration of membrane rupture 6 hrs 48 min) N = 219.
Exclusion: women undergoing elective CS (not defined further); antibiotics prior to procedure.
Interventions Intervention:
  • metronidazole 500 mg IV after cutting of cord;

  • N = 109.


Comparison: placebo:
  • placebo;

  • N = 110.

Outcomes Fever (temperature ≥ 38oC); wound infection, endometritis, sepsis (temperature > 38.5oC and bacteremia); abscess of pouch of Douglas (1 in each group).
Notes Translated from German.
Class of antibiotic: nitroimidazole (metronidazole).
Subgroups:
  • type of CS unclear;

  • after cord clamping.


The groups were comparable in respect of social status, age, parity, duration of pregnancy, primary section/repeat section, axillary temperature before the procedure, localization of skin incision, number of amnioscopes.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "Randomly" divided into 2 groups.
Comment: no description of sequence generation process.
Allocation concealment (selection bias) Unclear risk Comment: no information provided.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Comment: no losses or exclusions reported; it appears the analysis was ITT.
Selective reporting (reporting bias) Unclear risk Comment: insufficient information to judge.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Comment: placebo‐controlled; no additional information provided.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Comment: insufficient information to judge.
Other bias Low risk Comment: no other sources of bias identified.