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. 2014 Oct 28;2014(10):CD007482. doi: 10.1002/14651858.CD007482.pub3

Heilmann 1984.

Methods Randomized trial; 2 parallel groups.
Unit of randomization: individual.
Participants Dates of data collection: not stated.
Setting: Essen, Germany.
Inclusion criteria: women undergoing CS in labor (classified as non‐elective).
Exclusion criteria: none reported.
Interventions Intervention 1:
  • cefoxitin 2 g within 3 minutes of anesthetic induction;

  • N = 30.


Intervention 2:
  • no treatment;

  • N = 30.

Outcomes Febrile morbidity (oral temperature > 30°C for at least 2 days); wound infection (reported as "healing difficulties" in translation of table); UTI (105 bacteria/mL after removal of the catheter); length of post‐operative stay.
Notes Translated from German.
Class of antibiotic: cefamycin (2nd generation cephalosporin).
Subgroups:
  • non‐elective CS;

  • before cord clamping.


The groups were comparable for age, weight, duration of operation, birthweight, duration of urinary catheter use, premature rupture of membranes > 12 hrs; intrauterine fetal monitoring; birthweight.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Quote: "open randomization".
Comment: no additional information provided; no description of sequence generation process.
Allocation concealment (selection bias) Unclear risk Comment: no information provided.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: no loss to follow‐up; analysis was ITT.
Selective reporting (reporting bias) Unclear risk Insufficient information provided.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: no blinding; not placebo‐controlled.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: probably outcome assessment was not blinded.
Other bias Low risk Comment: no other sources of bias identified.