Tzingounis 1982.

Methods	Randomized, placebo‐controlled trial; 2 parallel groups. Unit of randomization: individual.
Participants	Date of data collection: not reported. Setting: Alexandra Maternity Hospital, Athens, Greece. Inclusion criteria: women in labor (non‐elective). N = 96. Exclusion criteria: acute bleeding due to abruptio placentae, established infection.
Interventions	Intervention: 2nd generation cephalosporin: cefuroxime 750 mg IV 1 hr or less before surgery and every 8 hrs for 72 hrs; N = 46. Comparison: placebo: matching placebo (comparable in appearance and viscosity); N = 50.
Outcomes	Febrile morbidity (oral temperature of > 100.3oF twice 6 hrs apart) and infection of endometrium, urinary tract and wound (not defined); results of duration of maternal stay only provided for febrile patients.
Notes	No patients had any major complications from the use of cefuroxime. Class of antibiotic: 2nd generation cephalosporin. Subgroups: non‐elective CS; before cord clamping.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Selected in a random manner". Comment: no description of sequence generation process.
Allocation concealment (selection bias)	Unclear risk	Comment: no information was provided.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Comment: no loss to follow‐up; no participants excluded. ITT analysis.
Selective reporting (reporting bias)	Unclear risk	Comment: insufficient information to judge.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Quote: "double‐blind".... "the placebo was comparable to cefuroxime in both appearance and viscosity of solution".
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: insufficient information to judge.
Other bias	Low risk	Comment: no other sources of bias identified.