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. 2014 Oct 28;2014(10):CD007482. doi: 10.1002/14651858.CD007482.pub3

Walss Rodriguez 1990.

Methods RCT; 2 parallel groups.
Unit of randomization: individual.
Participants Dates of data collection: July 1 to September 1988.
Setting: Coah, Mexico.
Inclusion criteria: women undergoing urgent CS. N = 120.
Exclusion: fever, chorioamnionitis, penicillin allergy, antibiotic treatment in prior 2 weeks.
Interventions Intervention:
  • ampicillin 2 g IV every 4 hrs x 3 after clamping of cord;

  • N = 59.


Comparison: no treatment:
  • no treatment;

  • N = 61.

Outcomes Febrile syndrome; wound infection; abdominal wall abscess; endometritis, length of hospital stay.
Notes No definitions of outcomes provided.
"Absceso de pared" has been translated as abdominal wall abscess.
Abdominal wall abscess, infection of surgical scar and spontaneous reopening of the wound + infection have been classified as "wound infection".
Class of antibiotic: aminopenicillin (ampicillin).
Subgroups:
  • type of CS unclear;

  • after cord clamping.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: Allocated "in random form" using a random table.
Allocation concealment (selection bias) Unclear risk Comment: no information provided.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk Comment: no losses or exclusions were reported. Analysis appears to be ITT.
Selective reporting (reporting bias) Unclear risk Comment: insufficient information to judge.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Comment: no blinding, not placebo‐controlled.
Blinding of outcome assessment (detection bias) 
 All outcomes High risk Comment: probably outcome assessment was not blinded.
Other bias Low risk Comment: no other sources of bias identified.