3. Evidence map.

Intervention	Cochrane Review	Number of included studies involving children (number of participants)	Potential new studies based on review search strategy	Overview team recommendations for new Cochrane Reviews, or changes to existing reviews	Overview team suggested research priorities based on evidence presented in this evidence map
Inhaled treatment
Continuous vs intermittent beta‐agonists	Camargo 2003	1 (70)	Rose 2011; Sabato 2011; Wilkinson 2018	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Combined inhaled anticholinergics and short‐acting beta‐agonists	Emergency department setting Griffiths 2013	20 (2632)	Supriyatno 2012; Sengul Gokalp 2013; Memon 2016	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
	Inpatient setting Vezina 2014	4 (472)	Wyatt 2015	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Inhaled magnesium sulfate	Knightly 2017	8 (1247)	Motamed 2017; Mustafa 2017	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Parenteral bronchodilators
Intravenous aminophylline	Mitra 2005	7 (380)	Naao 2007; Chen 2008; D'Avila 2008; Singhi 2014; Tiwari 2016	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Addition of intravenous beta2‐agonists to inhaled beta2‐agonists	Travers 2012a	2 (73)	Aubuchon 2012; Schneider 2012; House 2015	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Intravenous beta2‐agonists vs intravenous aminophylline	Travers 2012b	4 (168)	Singhi 2014	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Intravenous magnesium sulfate	Griffiths 2016	5 (182)			Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Ketamine	Jat 2012	1 (68)			Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Interventions to reduce the work of breathing
Heliox	Rodrigo 2006	3 (82)	Bigham 2010; Brandão 2011; Ortiz 2012; Morimoto 2018	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Non‐invasive positive‐pressure ventilation	Korang 2016	2 (40)	Navanandan 2017	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
High‐flow nasal oxygen therapy	No review	N/A		New review needed	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Other interventions
Antibiotics	Normansell 2018	3 (133)	Mandhane 2017	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials
Leukotriene receptor antagonists	Watts 2012	4 (470)	Adachi 2012; Matsuse 2012; Zubairi 2013; Kanchanateeraphong 2014; Magazine 2016; Chaudhury 2017; Magazine 2018; Wang 2018	Update review	Compare effectiveness in preschool and older children Develop and use core outcome measures, consistent assessment of asthma severity at study entry, and consistent inclusion criteria in future trials