5. ROBIS assessment of included reviews.

Review	Domain 1: study eligibility criteria	Domain 2: identification and selection of studies	Domain 3: data collection and study appraisal	Domain 4: synthesis and findings	Risk of bias in the review
Inhaled treatment
Camargo 2003	Low concern	Low concern	Low concern	Low concern	Low risk
Griffiths 2013	Low concern	High concern	Low concern	Low concern	High risk
Vezina 2014	Low concern	High concern	Low concern	Low concern	High risk
Knightly 2017	Low concern	High concern	Low concern	Low concern	High risk
Parenteral treatment
Mitra 2005	Low concern	High concern	Unclear concern	Low concern	High risk
Travers 2012a	Low concern	Low concern	Low concern	Low concern	Low risk
Travers 2012b	Low concern	Low concern	Low concern	Low concern	Low risk
Griffiths 2016	Low concern	Low concern	Low concern	Low concern	Low risk
Jat 2012	Low concern	Low concern	Low concern	Low concern	Low risk
Other interventions to reduce the work of breathing
Rodrigo 2006	Low concern	Low concern	Low concern	Low concern	Low risk
Korang 2016	Low concern	Low concern	Low concern	Low concern	Low risk
Other interventions
Normansell 2018	Low concern	Low concern	Low concern	Low concern	Low risk
Watts 2012	Low concern	Low concern	Low concern	Low concern	Low risk

Complete details of all components of the ROBIS assessment are presented in Appendix 4.