Outcome category	Outcome	Specific outcome measure used	Reviews
Length of stay	Emergency department length of stay	ED treatment time (units not specified)	Camargo 2003
		ED treatment time (minutes)	Griffiths 2016
	Hospital length of stay	Length of hospital stay (days)	Normansell 2018
		Length of hospital stay (hours)	Mitra 2005; Travers 2012b; Vezina 2014; Griffiths 2016
	PICU length of stay	PICU length of stay (hours)	Travers 2012a
Hospital admission	Hospital admission rate	Hospital admission rate	Camargo 2003; Rodrigo 2006; Jat 2012; Watts 2012; Griffiths 2013; Griffiths 2016; Knightly 2017
Intensive care unit admission	Intensive care unit admission	HDU/ICU admission rates	Mitra 2005; Vezina 2014; Knightly 2017
Adverse effects	All adverse effects	All adverse events	Normansell 2018
		Adverse health effects	Vezina 2014
		Any adverse event (during admission)	Knightly 2017
		Any adverse events	Knightly 2017
	Serious adverse events	Serious adverse events	Korang 2016; Knightly 2017; Normansell 2018
		Serious adverse events (during admission)	Knightly 2017
	Death	Death	Mitra 2005
		Mortality	Korang 2016
	Tremor	Tremor	Camargo 2003; Mitra 2005; Travers 2012b; Griffiths 2013
	Nausea/vomiting	Nausea/vomiting	Camargo 2003; Travers 2012b
		Vomiting	Mitra 2005; Travers 2012b; Griffiths 2013
		Nausea	Travers 2012b; Griffiths 2013
	Cardiovascular adverse effects	Hypotension	Knightly 2017
		Flushing	Knightly 2017
		Arrhythmia	Mitra 2005
		Dysrhythmia	Travers 2012b
		Palpitations	Travers 2012b
	Neurological adverse effects	Headache	Mitra 2005; Travers 2012b
		Seizures	Mitra 2005
	Pneumonia	Pneumonia	Korang 2016
	Abnormal laboratory results	CPK elevation	Travers 2012b
		CPK‐MB elevation	Travers 2012b
		Hyperglycaemia	Travers 2012b
		Hypokalaemia	Travers 2012b
Symptom scores	Symptom scores	Symptom scores	Camargo 2003
		Change in clinical score at 120 minutes (± 30 minutes)	Griffiths 2013
		Change in pulmonary index score (final assessment)	Watts 2012
		Dyspnoea or pulmonary index	Rodrigo 2006
		Asthma clinical scores 8 to 36 hours after initial treatment	Vezina 2014
		Yung asthma severity score at 60 minutes	Knightly 2017
		Change in symptom scores 6 to 8 hours after enrolment	Mitra 2005
		Change in symptom scores 12 to 18 hours after enrolment	Mitra 2005
		Change in symptom scores 24 hours after enrolment	Mitra 2005
		Pulmonary index score	Jat 2012
		Asthma symptom score in the acute phase	Korang 2016
Lung function	Peak expiratory flow	PEFR values (end of study)	Camargo 2003
		Peak expiratory flow (L/min)	Normansell 2018
		Percentages of predicted PEFR at 8 to 36 hours after initial treatment	Vezina 2014
		Pulmonary function PEF L/min	Knightly 2017
		Change in PEF 6 to 8 hours after enrolment	Mitra 2005
		Change in PEF 12 to 18 hours after enrolment	Mitra 2005
		Change in PEF 24 hours after enrolment	Mitra 2005
	Pulmonary function	Pulmonary function	Rodrigo 2006
	Forced expiratory volume – one second	Change in %predicted FEV1 within 4 hours of enrolment	Mitra 2005
		Change in %predicted FEV1 6 to 8 hours after enrolment	Mitra 2005
		Change in %predicted FEV1 12 to 18 hours after enrolment	Mitra 2005
		Change in %predicted FEV1 24 hours after enrolment	Mitra 2005
		Pulmonary function %predicted FEV1	Knightly 2017
		Change in FEV1 (predicted)	Watts 2012
		Change in FEV1 (litres)	Watts 2012
		Change from baseline in %predicted FEV1, 60 minutes after last dose of inhaled bronchodilator	Griffiths 2013
		Change from baseline in %predicted FEV1, 120 minutes after last dose of inhaled bronchodilator	Griffiths 2013
	FEV1 or PEFR	%Change in FEV1 or PEFR at 60 minutes after last inhaled bronchodilator (± 15 minutes)	Griffiths 2013
		%Change in FEV1 or PEFR at 120 minutes after last inhaled bronchodilator (± 30 minutes)	Griffiths 2013
	Respiratory resistance	%Change in respiratory resistance at 60 minutes after inhaled bronchodilator (± 15 minutes)	Griffiths 2013
		%Change in respiratory resistance at 120 minutes after inhaled bronchodilator (± 30 minutes)	Griffiths 2013
Vital signs	Oxygen saturations	Oxygen saturations < 95% at 60 minutes (± 15 minutes)	Griffiths 2013
		Oxygen saturations < 95% at 120 minutes (± 30 minutes)	Griffiths 2013
		SaO2	Rodrigo 2006
	Pulse rate	Pulse rate (beats/min) at 2 hours	Travers 2012a
	Respiratory rate	Change in respiratory rate (breaths/min) (final assessment)	Watts 2012
	Blood pressure	Blood pressure	Mitra 2005
Mechanical ventilation	Mechanical ventilation	Rates of patients mechanically ventilated in ICU	Mitra 2005
Clinical failure	Clinical failure	Clinical failure	Travers 2012a; Travers 2012b
Relapse	Relapse/return to hospital	Relapse	Griffiths 2013
		Relapse within 7 days	Watts 2012
		Relapse within 72 hours of discharge from hospital	Vezina 2014
		Return to ED within 48 hours	Griffiths 2016
Withdrawals	Withdrawals	Withdrawals	Watts 2012
		Overall withdrawals	Vezina 2014
		Withdrawals due to deterioration	Vezina 2014
		Withdrawals due to adverse health effects	Mitra 2005
		Withdrawals due to poor asthma control	Mitra 2005
Treatment intensity	Respiratory therapist time	Respiratory therapist time	Camargo 2003
	Frequency of nebuliser treatment	Time to SABA spaced at 4 hours or longer (hours)	Vezina 2014
		Number of nebulisers required in 24 hours	Mitra 2005
Need for additional treatment	Need for further treatment after study medication	Need for repeat bronchodilator treatment after standard protocol prior to disposition	Griffiths 2013
		Need for corticosteroids in ED prior to disposition	Griffiths 2013
		Requirement for additional care at end of study	Watts 2012
		Need for supplemental asthma therapy	Vezina 2014
		Worsened and required other adjuvant therapy	Jat 2012