9.

Forest plots of sensitivity and specificity of the combination of alpha‐foetoprotein and ultrasound against different reference standards in 8 studies ordered by increasing sensitivity.Rreference standards were: the pathology of the explanted liver in case of transplantation.;the histology of resected focal liver lesion(s), or the histology of biopsied focal liver lesions with a follow‐up period of at least six months, typical characteristics on cross‐sectional multiphasic contrast CT or MRI, with a follow‐up period of at least six months. TP = true positive; FP = false positive; FN = false negative; TN = true negative. Values between brackets are the 95% confidence intervals (CIs) of sensitivity and specificity. The figure shows the estimated sensitivity and specificity of the study (blue square) and its 95% CI (black horizontal line)