Comparison 2. Any CNTF versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Deaths	2	1300	Risk Ratio (M‐H, Fixed, 95% CI)	1.07 [0.81, 1.41]
2 Muscle strength	2	1300	Mean Difference (IV, Fixed, 95% CI)	‐0.04 [‐0.10, 0.03]
3 Respiratory function (FVC %)	2	1300	Mean Difference (IV, Fixed, 95% CI)	0.96 [‐1.65, 3.58]
4 Changes in quality of life (SIP)	1	503	Mean Difference (IV, Fixed, 95% CI)	‐0.74 [‐2.50, 1.02]
5 Cough	1	570	Risk Ratio (M‐H, Fixed, 95% CI)	1.55 [1.10, 2.17]
6 Asthenia	1	570	Risk Ratio (M‐H, Fixed, 95% CI)	1.02 [0.81, 1.28]
7 Nausea	1	570	Risk Ratio (M‐H, Fixed, 95% CI)	1.35 [0.92, 1.99]
8 Anorexia	1	570	Risk Ratio (M‐H, Fixed, 95% CI)	1.66 [1.09, 2.51]
9 Increased salivation	1	570	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.78, 1.50]