5. Diagnostic accuracy of Xpert MTB/RIF and Xpert Ultra for tuberculous meningitis and lymph node tuberculosis.
| Test, analysis group |
Reference standard |
Studies | Number of children (TB cases) | Sensitivity % (95% CI) | Specificity % (95% CI) | Positive predictive value % (95% CI)a | Negative predictive value % (95% CI)a |
| Xpert MTB/RIF, CSF | Culture | 6 | 262 (28) | 54.0 (27.8 to 78.2) | 93.8 (84.5 to 97.6) | 49.1 (26.8 to 71.7) | 94.8 (91.1 to 97.1) |
| Xpert MTB/RIF, CSFb | Composite | 3 | 160 (94) | − | − | − | − |
| Xpert MTB/RIF, Lymph node | Culture | 6 | 210 (54) | 90.4 (55.7 to 98.6) | 89.8 (71.5 to 96.8) | 49.6 (23.7 to 75.7) | 98.8 (93.1 to 99.8) |
| Xpert MTB/RIF, Lymph nodeb | Composite | 3 | 107 (63) | − | − | − | − |
CI: confidence interval; CSF: cerebrospinal fluid; TB: tuberculosis.
aPredictive values were determined at a pre‐test probability of 10%. bWe did not perform a meta‐analysis owing to limited data.