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. 2020 Aug 15;16(5):495–502. doi: 10.1080/15592294.2020.1805692

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 1. — Comparison of ICC values for raw and preprocessed data. Shown are the ICCs calculated based on the 128 technical replicates with 450 K methylation data. Data preprocessing steps include either ENmix background correction, RELIC dye-bias correction, quantile normalization and RCP probe type bias correction (ENmix+RCP) or noob background correction, Illumina dye-bias correction, quantile normalization and BMIQ probe type bias correction (noob+BMIQ). The x-axis labels are the ICC median of each bin