Table 3.
Pathway analysis of genes near top CpG sites associated with asthma in the meta-analysis of data from 1,136 Latino children
| Ingenuity Canonical Pathway | -log(p-value) | Molecules |
|---|---|---|
| TGF-β Signalling | 3.97 | ZNF423,RUNX3,SKI,SMAD7,PITX2,PMEPA1 |
| Phototransduction Pathway | 2.09 | RGS9,GUCY1A1,GNGT1 |
| Semaphorin Signalling in Neurons | 1.94 | RND3,RHOBTB1,SEMA7A |
| Role of JAK1, JAK2 and TYK2 in Interferon Signalling | 1.83 | PTPN6,IFNAR1 |
| Th1 and Th2 Activation Pathway | 1.8 | RUNX3,CCR8,PSEN2,NFATC1,IFNAR1 |
| Actin Nucleation by ARP-WASP Complex | 1.73 | ARPC1B,RND3,RHOBTB1 |
| CD28 Signalling in T Helper Cells | 1.68 | PTPN6,ARPC1B,CARD11,NFATC1 |
| Th1 Pathway | 1.65 | RUNX3,PSEN2,NFATC1,IFNAR1 |
| L-carnitine Biosynthesis | 1.63 | BBOX1 |
| D-glucuronate Degradation I | 1.63 | CRYL1 |
| BMP signalling pathway | 1.54 | ZNF423,SMAD7,PITX2 |
| Ascorbate Recycling (Cytosolic) | 1.51 | GLRX |
| Glutathione Redox Reactions II | 1.51 | GLRX |
| Melatonin Degradation II | 1.51 | IL4I1 |
| Antiproliferative Role of Somatostatin Receptor 2 | 1.48 | PTPN6,GUCY1A1,NPR1 |
| Regulation of Actin-based Motility by Rho | 1.43 | ARPC1B,RND3,RHOBTB1 |
| Glycogen Biosynthesis II (from UDP-D-Glucose) | 1.34 | UGP2 |
| Hepatic Fibrosis/Hepatic Stellate Cell Activation | 1.24 | COL5A1,SMAD7,IFNAR1,COL7A1 |
| Sphingosine and Sphingosine-1-phosphate Metabolism | 1.22 | SGPP2 |
| Salvage Pathways of Pyrimidine Deoxyribonucleotides | 1.22 | TK2 |
| T Cell Exhaustion Signalling Pathway | 1.21 | PTPN6,PRDM1,NFATC1,IFNAR1 |
| Retinoic acid Mediated Apoptosis Signalling | 1.1 | PARP8,IFNAR1 |
| Natural Killer Cell Signalling | 1.07 | PTPN6,KLRB1,SH3BP2 |
| Adipogenesis pathway | 1.06 | ZNF423,LPIN1,HDAC7 |
| GP6 Signalling Pathway | 1.05 | COL5A1,COL7A1,RASGRP2 |