Figure 6.

Schematic depicting the CGAS-STING1 pathway that is implicated in mtDNA stress-induced ferroptotic cancer cell death via the activation of autophagy. Zalcitabine induces oxidative mtDNA damage and decreased mitochondrial function as well as degradation of the mitochondrial transcription factor TFAM. These effects result in the activation of the DNA damage sensing CGAS-STING1 pathway, inducing autophagy and subsequently causing autophagy-dependent ferroptosis. See the text for details.`