Table 3.

Percentages of toddlers with pneumococcal serotype-specific OPA titers above or equal to the assay serotype-specific LLOQ and OPA GMTs, by timepoint (according-to-protocol cohort for immunogenicity)

		12vPHiD-CV				PHiD-CV
		N	% (95% CI)	GMT (95% CI)		N	% (95% CI)	GMT (95% CI)
6A	Pre	12	25.0 (5.5–57.2)	142.3 (66.4–304.8)		7	28.6 (3.7–71.0)	144.4 (51.8–402.1)
	Post	24	100 (85.8–100)	4515.3 (3426.5–5950.0)		17	82.4 (56.6–96.2)	1165.4 (571.8–2375.1)
19A	Pre	13	30.8 (9.1–61.4)	208.7 (73.0–596.7)		6	50.0 (11.8–88.2)	251.6 (55.2–1145.5)
	Post	25	100 (86.3–100)	5109.3 (3850.7–6779.4)		20	95.0 (75.1–99.9)	2796.3 (1708.7–4576.4)

OPA, opsonophagocytic activity; LLOQ, lower limit of quantitation; N, number of toddlers with available results in each group; GMT, geometric mean titer; CI, confidence interval; Pre, pre-vaccination; Post, 1 month post-vaccination.

Note: The assay LLOQ was 151 for serotype 6A and 143 for serotype 19A.