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C. butyricum strains improve gut barrier function by increasing the thickness of the mucosal layer and increasing expression of TJ proteins. Increased expression of TJ proteins may also result from C. butyricum’s stimulation of IL-17 production from intraepithelial T cells. This improved barrier results in decreased permeation of LPS and pathogenic bacteria into host tissue and blood
TJ: tight junction; IL-17: interleukin-17; LPS: lipopolysaccharide
