Table 2:
Proposed Acute Skin Failure Variables by Domain
| ASF Domain (bolded)/Risk Factor |
Category | HAPI (N = 165) |
Control (N = 310) |
Total (N = 475) |
P Value |
|---|---|---|---|---|---|
| Organ Failure | |||||
| Any Type Organ Failure | No | 9 (5.5%) | 161 (51.9%) | 170 (35.8%) | <.001 |
| Yes | 156 (94.5%) | 149 (48.1%) | 305 (64.2%) | ||
| Respiratory Failurea | No | 32 (19.4%) | 187 (60.3%) | 219(46.1%) | <.001 |
| Yes | 133 (80.6%) | 123 (39.7%) | 256 (53.9%) | ||
| Renal (Acute or Chronic) Failurea | No | 61 (37.0%) | 266 (85.8%) | 327 (68.8%) | <.001 |
| Yes | 104 (63.0%) | 44 (14.2%) | 148 (31.2%) | ||
| Cardiac Failurea | No | 125 (75.8%) | 283 (91.3%) | 408 (85.9%) | <.001 |
| Yes | 40 (24.2%) | 27 (8.7%) | 67 (14.1%) | ||
| Liver Failurea | No | 145 (87.9%) | 303 (97.7%) | 448 (94.3%) | <.001 |
| Yes | 20 (12.1%) | 7 (2.3%) | 27 (5.7%) | ||
| Limited Tissue Perfusion | |||||
| Any Type | No | 110 (66.7%) | 278 (89.7%) | 388 (81.7%) | <.001 |
| Yes | 55 (33.3%) | 32 (10.3%) | 87 (18.3%) | ||
| Myocardial Infarction Diagnosed during Current Admission | No | 161 (97.6%) | 295 (95.2%) | 456 (96.0%) | 0.201 |
| Yes | 4 (2.4%) | 15 (4.8%) | 19 (4.0%) | ||
| Severe Anemia (Hemoglobin < 7 g/dL) a | No | 115 (69.7%) | 301 (97.1%) | 416 (87.6%) | <.001 |
| Yes | 50 (30.3%) | 9 (2.9%) | 59 (12.4%) | ||
| Vasopressor Use Resulting in Peripheral Necrosis (Toes, Fingers) | No | 164 (99.4%) | 310 (100.0%) | 474 (99.8%) | 0.347 |
| Yes | 1 (0.6%) | 0 (0.0%) | 1 (0.2%) | ||
| Peripheral Arterial Disease (PAD) | No | 165 (100.0%) | 310 (100.0%) | 475 (100.0%) | NA |
| Cardiac Arrest Sustained during Current Admission | No | 162 (98.2%) | 300 (96.8%) | 462 (97.3%) | 0.557 |
| Yes | 3 (1.8%) | 10 (3.2%) | 13 (2.7%) | ||
| Sepsis Continuum | |||||
| Any Type Sepsisa | No | 98 (59.4%) | 274 (88.4%) | 372 (78.3%) | <.001 |
| Yes | 67 (40.6%) | 36 (11.6%) | 103 (21.7%) | ||
| Sepsis | No | 100 (60.6%) | 289 (93.2%) | 389 (81.9%) | <.001 |
| Yes | 65 (39.4%) | 21 (6.8%) | 86 (18.1%) | ||
| Severe Sepsis | No | 123 (74.5%) | 297 (95.8%) | 420 (88.4%) | <.001 |
| Yes | 42 (25.5%) | 13 (4.2%) | 55 (11.6%) | ||
| Septic Shock | No | 127 (77.0%) | 300 (96.8%) | 427 (89.9%) | <.001 |
| Yes | 38 (23.0%) | 10 (3.2%) | 48 (10.1%) | ||
| MODS | No | 161 (97.6%) | 310 (100.0%) | 471 (99.2%) | 0.014 |
| Yes | 4 (2.4%) | 0 (0.0%) | 4 (0.8%) | ||
| Diabetes Diagnosisa | No | 111 (67.3%) | 229 (73.9%) | 340 (71.6%) | 0.129 |
| Yes | 54 (32.7%) | 81 (26.1%) | 135 (28.4%) | ||
| Mechanical Ventilation - Greater than 72 Hours? a | No | 77 (46.7%) | 230 (74.2%) | 307 (64.6%) | <.001 |
| Yes | 88 (53.3%) | 80 (25.8%) | 168 (35.4%) | ||
Note:
a.
Variables were included in multivariate logistic regression in Table 6.