Figure 7. Insulin-like growth factors influence the function of Th17-like ILC3s.
(A) Microarray data showing Igf1r and Igfbp transcript expression in ILCs from small intestine lamina propria. (B) ILC frequencies in Igf1rfl/fl and RorcCre/+.Igf1rfl/fl small intestine lamina propria (n=6). (C) IL-17a and IL-22 production by ILC3s isolated from small intestine lamina propria after stimulation with 10 ng/ml IL-23 in vitro for 3 h (n=6). Graphs depict mean +/– SD. ns: not significant, *p≤0.05, **p≤0.01, ***p≤0.001.