Figure 3.

Non-histone protein methylation by SETD1A. The figure illustrates the pathway by which SETD1A regulates cancer cell proliferation by protein methylation. (a) SETD1A mono-methylates YAP (at K342) which interacts with transcriptional factor, TEAD and promotes the expression of target genes. (b) Di-methylation of HSP70 at K561 by SETD1A regulates the cell cycle progression. The di-methylated HSP70 binds to AURKB, which in turn interacts with INCENP, resulting in kinase activation of AURKB and formation of CPC, essential for mitotic progression. YAP: Yes associated protein; K: Lysine; TEAD: TEA domain; TSS: Transcription start site; HSP70: Heat shock protein 70; AURKB: Aurora kinase B; INCENP: Inner centromere protein; CPC: Chromosomal passenger complex