Table 1.

Non-canonical functions of SET1 family members

SET1 family member	Non-canonical roles	Loss of function	References
MLL	Spindle organization	Elongated spindles with dense or low microtubule formation/multipolar spindle formation.	[130]
	Chromosomal alignment and segregation	Delayed chromosomal alignment at metaphase plate. Formation of micronuclei.	[111,130]
	Cytokinesis	Formation of binucleated cells.	[111,135]
	Cell proliferation	Growth arrest at G1 Phase/defects in S-Phase progression.	[111]
	Ubiquitination process (as E3 ligase)	Delayed degradation and increased stability of MLL.	[184]
MLL2	Cell proliferation	Defects in S-Phase progression.	[111]
	Ubiquitination process, as E3 ligase	Delayed degradation and increased stability of MLL2.	[184]
MLL3	Cell proliferation	Defects in S-Phase progression.	[111]
	Transcriptional coactivator, Pol II loading and eRNA synthesis at enhancers	Reduces Pol II density in adjacent gene-bodies.	[96]
MLL4	Cell proliferation	Defects in S-Phase progression	[111]
	Transcriptional coactivator, Pol II loading and eRNA synthesis at enhancers	Reduces Pol II density in adjacent gene-bodies.	[96]
SETD1A	DNA damage response	Supresses DDR genes and induces p53-dependent apoptosis/impaired DDR	[120,123]
	Chromosomal alignment and segregation	Delayed chromosomal alignment at metaphase plate. Formation of micronuclei.	[111,130]
	Cytokinesis	Formation of binucleated cells.	[111]
	Non-histone protein methylation	Reduced cellular proliferation in cancer cells.	[168,173]
	Cell proliferation/viability	Induced growth arrest	[120]
SETD1B	Metabolic processes	Reduction in HADHA, a mitochondrial trifunction protein and thus leads to accumulation of lipids.	[32]
	Cell proliferation/ viability	Altered cancer cell survival and growth.	[32]