Table 3. Altered matrisome-associated genes in stromal cells derived from lung ADC compared to normal lung.
| Matrisome division | Matrisome category | Gene symbol | Gene name | Log2FC ADC/Control |
|---|---|---|---|---|
| Core matrisome | Collagens | COL11A1 | collagen, type XI, alpha 1 | 1.33 |
| ECM Glycoproteins | MFAP5 | microfibrillar associated protein 5 | 1.31 | |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | -1.13 | ||
| POSTN | periostin, osteoblast specific factor | 1.70 | ||
| RELN | reelin | -1.63 | ||
| RSPO3 | R-spondin 3 | 1.02 | ||
| Proteoglycans | ACAN | aggrecan | -1.06 | |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 | 1.22 | ||
| Matrisome-associated | ECM Regulators | CSTA | cystatin A (stefin A) | 1.97 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 1.16 | ||
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 1.29 | ||
| Secreted Factors | CHRDL1 | chordin-like 1 | -1.21 | |
| CRLF1 | cytokine receptor-like factor 1 | 1.47 | ||
| S100A4 | S100 calcium binding protein A4 | 1.22 | ||
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | 1.02 |
List of differentially expressed genes between ADC and control was generated using log2FC lower than -1 or higher than 1 and the differentially expressed genes were annotated with Matrisome annotator [22]. ADC, adenocarcinoma; ECM; extracellular matrix; log2FC, log2 fold change.