Table 8. The % of bsf trypomastigotes inhibited by pentamidine/pluronic combinations.
The combination formulation was tested in triplicate and repeated in 3 separate experiments (n = 3).
| Pentamidine (μM) | ||||||
|---|---|---|---|---|---|---|
| 1 | 0.3 | 0.000152 | 5.1 x 10−5 | 1.7 x 10−5 | 5.7 x 10−6 | |
| F68 (w/v %) | ||||||
| 0.5% | 99.5% | 98.6% | 98.6% | 98.3% | 98.3% | 99.2% |
| 0.1% | 98.5% | 97.7% | 97.1% | 97.1% | 97.3% | 97.7% |
| 0.025% | 98.3% | 97.5% | 97.0% | 96.9% | 97.0% | 90.6% |
| 0.01% | 98.4% | 97.6% | 96.4% | 95.1% | 82.8% | 3.4% |
| 0.001% | 98.3% | 97.4% | 96.4% | 91.9% | 73.1% | 1.8% |
| 0% | 98.3% | 97.4% | 92.7% | 65.3% | 35.0% | 4.1% |