FIG 5.

Clinical outcomes by NCI-MPACT aMOIs. Cycles of treatment, best response, and limited demographic information for each randomly assigned and treated patient. Each patient's detected NCI-MPACT aMOIs are listed and color-coded to indicate the level of evidence that the mutation is susceptible to the assigned NCI-MPACT treatment (based on the information in the OncoKB and CIViC precision oncology knowledge bases at the time of writing). Where available, the results of whole exome sequencing are presented as the number of genetic alterations detected that are annotated in OncoKB as either oncogenic (# oncogenic mutations) or as oncogenic and actionable with available therapeutic agents (# OncoKB mutations). aMOI, actionable mutation of interest; CUP, cancer of unknown primary; dx, diagnosis; Illness, intercurrent illness required patient come off study; MPACT, molecular profiling-based assignment of cancer therapy; NR, no response; PD, progressive disease; PR, partial response; Prior Tx, number of lines of prior therapy; SD, stable disease; TMZ, temozolomide; Toxicity, study agent toxicity required patient come off study; Tx, treatment; uPR, unconfirmed partial response.