. 2021 Apr 19;10:e67310. doi: 10.7554/eLife.67310

Table 2. Characterization of representative mutants resistant to both ertapenem and meropenem or to ertapenem alone.

Mutant ID	Ancestor	Mutations causing decreased susceptibility	Gene function	Fold changes of MICs compared to ancestor strains
Mutant ID	Ancestor	Mutations causing decreased susceptibility	Gene function	ETP	MEM
Mutants resistant to ertapenem alone
Mut87	MGH21	wzc (L367_02683): c.381delA	Exopolysaccharide biosynthesis	2	1
Mut86	MGH21	ompA (L367_001084): p.G31D	Porin	2	1
Mut131	MGH21	ompK36 (L367_002817), c.332_333insTACGACCGTAGT	Porin	256	1
Mut101	UCI38	rseA (P841_001338):: IS1	Anti-sigma E factor, involved in maintaining cell envelope integrity	8	1
Mut34	UCI38	bla_SHV-12 (P841_005417) dup[2]	ESBL	8	1
Mutants resistant to ertapenem and meropenem
Mut21	MGH21	bamD (L367_003146): c.-4C > T	Outer membrane protein assembly factor	8	2
Mut136	MGH21	omp36K (L367_002817): p.Q311STP	Porin	64	8
Mut41	UCI38	ompK36 (P841_001022):: IS1	Porin	64	8
Mut107	UCI38	ompK36 (P841_001022):: IS5	Porin	64	16
Mut45	UCI38	ompK36 (P841_001022):: IS91	Porin	64	16