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. 2021 Apr 27;10:e60824. doi: 10.7554/eLife.60824

Figure 4. Changes in mean firing rate and spike-phase modulation during Awake vs. Unconscious states.

(A) Spike rate for all recorded areas averaged across all propofol-only recording sessions locked to loss of consciousness (LOC). (B) Same as A, but for recovery of consciousness (ROC). Mean and 99 percent confidence interval. (C/E/G/I) The spike-triggered average for all well-isolated units in a given area with respect to that area’s unfiltered LFP. Red is the Unconscious state, blue is the Awake state. (D/F/H/J) Boxplots of SNRɸ values in decibels (dB) (reflecting SF modulation of spiking, see 'Methods') for all units during the Awake and Unconscious states. PFC: prefrontal cortex; PPC: posterior parietal cortex 7A/7B; 8A: caudal lateral PFC; STG: superior temporal gyrus.

Figure 4.

Figure 4—figure supplement 1. Effect sizes for change in spiking during the Unconscious state.

Figure 4—figure supplement 1.

(A) Mean spike rates (spikes per second) during the Awake (blue bars) vs. Unconscious (orange bars) states. Mean +/- 1 SEM across all neurons. (B) The dB change in spiking, averaged across all units per area. Negative values indicate less spiking during the Unconscious state. Mean ±/- 1 SEM across all units per area. PFC: prefrontal cortex; PPC: posterior parietal cortex 7A/7B; 8A: caudal lateral PFC; STG: superior temporal gyrus.