(A) Firing rate change from Awake to Unconscious states as a function of cortical layer. Negative values indicate less spiking during the Unconscious state. Layer 0 is the approximate location of cortical layer 4 (see 'Methods'). The horizontal dotted line at zero separates superficial layers 2/3 from deep layers 5/6. Mean and 99 percent confidence interval of the effect size across all neurons per indicated depth. (B) Mean and 99 percentconfidence interval of the effect size across all superficial (N = 287) and deep (N = 337) neurons. (C, D) Same as A, B, but for LFP power at gamma (100–200 Hz). (E, F) Same as A, B, but for SF power (0.2–1.1 Hz). Positive values indicate more power during the Unconscious state. N = 330 LFPs for superficial layers, N = 393 LFPs for deep layers. Mean and 99 confidence interval across all available LFPs in each layer.