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. Author manuscript; available in PMC: 2021 Jul 10.
Published in final edited form as: J Control Release. 2020 Apr 6;323:240–252. doi: 10.1016/j.jconrel.2020.03.040

Figure 5.

Figure 5.

Aptamer-based DDSs. (a) Using an uncanonical phosphoramidite, 5-FU is covalently incorporated into the sgc8 aptamer sequence during solid-phase synthesis. Reproduced with permission from ref. 95. Copyright 2014 American Chemical Society. (b) An RNA aptamer bearing an NF-κB decoy double-stranded oligonucleotide, serving also as intercalation sites to load Dox. Note that yellow highlights indicate possible Dox binding sites. Reproduced with permission from ref. 103. Copyright 2015 American Society of Gene & Cell Therapy.