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. Author manuscript; available in PMC: 2021 Jul 10.
Published in final edited form as: J Control Release. 2020 Apr 6;323:240–252. doi: 10.1016/j.jconrel.2020.03.040

Figure 7.

Figure 7.

Antigen-responsive DNA nanorobot for AND-gated drug release. (a) Front view of the closed nanorobot loaded with a protein payload (purple). Two DNA-aptamers fasten and close the barrel-shaped carrier (boxed region). (b) Opened nanorobot after protein displacement of aptamer locks. (c) Mechanism of cargo release. The lock duplex is destabilized when its antigen key (red) is present. The lock duplex consists of a DNA aptamer (blue) and a partially complementary strand (orange) with multiple thymine (T) spacers. Reproduced with permission from ref. 131. Copyright 2012 American Association for the Advancement of Science.