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. 2021 Mar 24;12(2):281–289. doi: 10.1055/s-0041-1722820

Table 3. Summary of magnetic resonance imaging findings in common flavivirus encephalitis.

Type Sites of affection Cranial MRI findings Associated findings
Abbreviations: CVST, cerebral venous sinus thrombosis; FLAIR, fluid-attenuated inversion recovery; JE, Japanese encephalitis; MRI, magnetic resonance imaging.
Japanese encephalitis - Thalami and substantia nigra are commonly involved
- Basal ganglia, pons, cerebral cortex, and cerebellum are sometime involved
- T2 and FLAIR hyperintensities in the affected areas with diffusion restricted in early acute stage and facilitated diffusion in subacute stage
- Rarely hemorrhage can be seen in JE
- Neurocysticercosis coinfection
- Rarely dengue coinfection can occur
- Rarely may associated with CVST
Dengue encephalitis - Thalami and basal ganglia are commonly affected
- Pons, medulla, cerebellum, corpus callosum, and cerebral cortex can be involved
- T2 and FLAIR hyperintensities with restricted diffusion
- Parenchymal or extra-axial bleed can be seen and which is more common in dengue encephalitis than JE
- Diffuse cerebral edema may be seen
- Cerebellitis is more common
- Cortical laminar necrosis
West Nile encephalitis - Brain stem, basal ganglia, and corona radiata commonly affected
- Thalami, cerebral cortex, an white matters may be involved
- Isolated diffusion restrictions in posterior limb of internal capsule/corona radiata
- T2 and FLAIR hyperintensities in brain stem, basal ganglia, thalami, etc.
- Meningitis changes seen
- Enhancement of cauda equina and lumbosacral nerve roots
- Spinal cord T2 hyperintensities can be seen
Tick-borne encephalitis - Cerebellum commonly affected
- Thalami, basal ganglia, and anterior horn cell of spinal cord may be affected
- Leptomeningitis along cerebellar folia and basal cisterns
- T2 and FLAIR hyperintensities in thalami, basal ganglia, and cerebellum
Murray Valley encephalitis
(Australian encephalitis)
- Thalami and brain stem commonly affected - Bilateral symmetrical T2 and FLAIR hyperintensities in thalami and brain stem
St. Louis encephalitis - Substantia nigra most commonly affected - T2 hyperintensities in substantia nigra -Myelitis can be seen rarely