Table 3. Summary of magnetic resonance imaging findings in common flavivirus encephalitis.
Type | Sites of affection | Cranial MRI findings | Associated findings |
---|---|---|---|
Abbreviations: CVST, cerebral venous sinus thrombosis; FLAIR, fluid-attenuated inversion recovery; JE, Japanese encephalitis; MRI, magnetic resonance imaging. | |||
Japanese encephalitis | - Thalami and substantia nigra are commonly involved - Basal ganglia, pons, cerebral cortex, and cerebellum are sometime involved |
- T2 and FLAIR hyperintensities in the affected areas with diffusion restricted in early acute stage and facilitated diffusion in subacute stage - Rarely hemorrhage can be seen in JE |
- Neurocysticercosis coinfection - Rarely dengue coinfection can occur - Rarely may associated with CVST |
Dengue encephalitis | - Thalami and basal ganglia are commonly affected - Pons, medulla, cerebellum, corpus callosum, and cerebral cortex can be involved |
- T2 and FLAIR hyperintensities with restricted diffusion - Parenchymal or extra-axial bleed can be seen and which is more common in dengue encephalitis than JE - Diffuse cerebral edema may be seen |
- Cerebellitis is more common - Cortical laminar necrosis |
West Nile encephalitis | - Brain stem, basal ganglia, and corona radiata commonly affected - Thalami, cerebral cortex, an white matters may be involved |
- Isolated diffusion restrictions in posterior limb of internal capsule/corona radiata - T2 and FLAIR hyperintensities in brain stem, basal ganglia, thalami, etc. - Meningitis changes seen |
- Enhancement of cauda equina and lumbosacral nerve roots - Spinal cord T2 hyperintensities can be seen |
Tick-borne encephalitis | - Cerebellum commonly affected - Thalami, basal ganglia, and anterior horn cell of spinal cord may be affected |
- Leptomeningitis along cerebellar folia and basal cisterns - T2 and FLAIR hyperintensities in thalami, basal ganglia, and cerebellum |
|
Murray Valley encephalitis (Australian encephalitis) |
- Thalami and brain stem commonly affected | - Bilateral symmetrical T2 and FLAIR hyperintensities in thalami and brain stem | |
St. Louis encephalitis | - Substantia nigra most commonly affected | - T2 hyperintensities in substantia nigra | -Myelitis can be seen rarely |