Table A1.
Completed clinical trials with a focus on developmental outcomes
| Title | Start date | Country | Target children with disabilities | Includes children with disabilities | Does not include or exclude | Excludes children with disabilities | |
|---|---|---|---|---|---|---|---|
| 1 | The Pakistan Early Childhood Development Scale Up Trial | 2009 | Pakistan | 1 | |||
| 2 | Iron Treatment for Young Children With Non-anemic Iron Deficiency | 2012 | Canada | 1 | |||
| 3 | Project Grow Smart: Intervention Trial of Multiple Micronutrients and Early Learning Among Infants in India | 2012 | India | 1 | |||
| 4 | Early Child Development and Nutrition in Guatemala | 2015 | Guatemala | 1 | |||
| 5 | Strong Families, Thriving Children “Sugira Muryango”_Activity C | 2018 | Rwanda | 1 | |||
| 6 | Implementation and Adoption of Care for Child Development in Day Care Centers | 2015 | Lebanon | 1 | |||
| 7 | CASITA Intervention for Children at Risk of Delay in Carabayllo, Peru | 2013 | Peru | 1 | |||
| 8 | Family Inclusive Early Brain Stimulation | 2014 | Nigeria | 1 | |||
| 9 | Applying Mindfulness for Economically Disadvantaged Families | 2016 | Hong Kong | 1 | |||
| 10 | Promoting Child Development Practices in the First Year of Life Through a Video Administered at Two Different Times | 2008 | Italy | 1 | |||
| 11 | Promoting Early School Readiness in Primary Health Care | 2005 | USA | 1 | |||
| 12 | Improving Early Childhood Development in Zambia | 2014 | Zambia | 1 | |||
| 13 | Early Intervention for Developmental Delay | 2014 | Taiwan | 1 | |||
| 14 | A Family Centered Intervention to Promote Optimal Child Development | 2013 | USA | 1 | |||
| 15 | Family Strengthening Intervention for Early Childhood Development (ECD) | 2014 | Rwanda | 1 | |||
| 16 | Screening for Therapy and Empowering Parents: A Pilot Study | 2015 | USA | 1 | |||
| 17 | Alliance for Family Strengthening: Improved Early Childhood Development in Rwanda | 2017 | Rwanda | 1 | |||
| 18 | Efficacy of Tools of the Mind for Enhancing Self-Control in Preschoolers | 2012 | Canada | 1 | |||
| 19 | Early Literacy Promotion Intervention | 2016 | USA | 1 | |||
| 20 | Zinc and Biobehavioral Development in Early Childhood | 2004 | Peru | 1 | |||
| 21 | The Effect of a Cash Transfer Program and Preventive Nutrition Packages on Household Welfare and Child Nutritional Status in Mali | 2014 | Mali | 1 | |||
| 22 | Enhancing Ugandan HIV-Affected Child Development With Caregiver Training | 2012 | Uganda | 1 | |||
| 23 | Early Intervention for Preterm Infants | 2006 | Taiwan | 1 | |||
| 24 | Effect of Improving Caregiving on Early Mental Health | 2000 | Russia | 1 | |||
| 25 | Testing the Effectiveness of Telephone-based Early Childhood Developmental Screening | 2015 | USA | 1 | |||
| 26 | Early Family-Centered Prevention of Drug Use Risk (Aka Early Steps) | 2003 | USA | 1 | |||
| 27 | Effect of Power Wheelchairs on the Development and Function of Young Children With Severe Physical Disabilities | 2002 | USA | 1 | |||
| 28 | Effect of Community Based Depression Management and Child Development | 2014 | Bangladesh | 1 | |||
| 29 | Play and Pre-Literacy Among Young Children | 2015 | Canada | 1 | |||
| 30 | Social and Communication Outcomes for Young Children With Autism | 2009 | USA | 1 | |||
| 31 | The Anemia Control Program: Early Intervention | 1992 | Chile | 1 | |||
| 32 | Early Psychosocial Stimulation Program for Children of Depressed Mothers | 2009 | Pakistan | 1 | |||
| 33 | Promoting Infant Mental Health in Foster Care | 2007 | USA | 1 | |||
| 34 | Addressing Systemic Health Disparities in Early Identification and Treatment of Autism Spectrum Disorder (ASD): ABCD Project | 2014 | USA | 1 | |||
| 35 | The MOM Program at the Children's Hospital of Philadelphia | 2001 | USA | 1 | |||
| 36 | Translating Evidence Based Developmental Screening Into Pediatric Primary Care | 2008 | USA | 1 | |||
| 37 | Improving Parental Psychosocial Functioning and Early Developmental Outcomes in Children With Sickle Cell Disease | 2014 | West Indies | 1 | |||
| 38 | Promoting Healthy Development With the Recipe 4 Success Intervention | 2013 | USA | 1 | |||
| 39 | Long Term Effect of Early Iron Supplementation and Psychosocial Stimulation on Growth and Development of Iron-deficient Anaemic Infants | 2015 | Bangladesh | 1 | |||
| 40 | Reduce Childhood Maltreatment and Promote Development | 2015 | Bangladesh | 1 | |||
| 41 | The Impact of Cash and Food Transfers Linked to Preschool Enrollment on Child Nutrition and Cognitive Outcomes | 2010 | Uganda | 1 | |||
| 42 | Effects of Family-Centered Intervention for Preterm Infants at Preschool Age | 2015 | Taiwan | 1 | |||
| 43 | Effectiveness of Parent-Child Interaction and Emotion Development Therapy in Treating Preschool Children With Depression | 2007 | USA | 1 | |||
| 44 | The Effects of Iodized Salt on Cognitive Development in Ethiopia | 2011 | Ethiopia | 1 | |||
| 45 | An Intervention for Enhancing Early Attachment in Primary Health Care | 2013 | Chile | 1 | |||
| 46 | The MOM Program: 5 Year Follow-up Study of a Home Visiting Program at the Children's Hospital of Philadelphia | 2004 | USA | 1 | |||
| 47 | Small Step Intervention for Infants With Cerebral Palsy and Other Neurodevelopmental Disorders | 2014 | Sweden | 1 | |||
| 48 | Intervention Effects of Intensity and Delivery Style for Toddlers With Autism | 2008 | USA | 1 | |||
| 49 | Motivational Interviewing to Increase Parent Engagement in Preventive Parenting Programming | 2013 | USA | 1 | |||
| 50 | Intensive Intervention for Toddlers With Autism (EARLY STEPS) | 2013 | USA | 1 | |||
| 51 | Optimizing Social and Communication Outcomes for Toddlers With Autism | 2008 | USA | 1 | |||
| 52 | Primary Prevention of Allergic Disease in Early Child by Lactobacillus reuteri | 2001 | Sweden | 1 | |||
| 53 | Intervention for Toddlers at Risk for Autism Spectrum Disorders (ASD) | 2008 | USA | 1 | |||
| 54 | Promoting Development in Toddlers With Communication Delays | 2007 | USA | 1 | |||
| 55 | Early Intervention, Supervision, Quality and Outcome in ASD | 2013 | Sweden | 1 | |||
| 56 | Differential DNA Methylation as a Function of a Parenting Intervention | 2013 | USA | 1 | |||
| 57 | Early Connections, Early Detection and Intervention in Infants at Risk for Autism | 2008 | USA | 1 | |||
| 58 | Early Characteristics of Autism | 2003 | USA | 1 | |||
| 59 | School- and Home-Based Early Intervention for Toddlers With Autism | 2003 | USA | 1 | |||
| 60 | Follow-up of Families in Early Preventive Intervention | 2000 | USA | 1 | |||
| 61 | Parent Training Program for Preschool Children With Autism Spectrum Disorders | 2015 | Taiwan | 1 | |||
| 62 | RESPECT-PLUS: Services for Infants With Prenatal Opiate Exposure | 2013 | USA | 1 | |||
| 63 | Early Nutritional Intervention in Patients With Autism Spectrum Disorders | 2010 | Qatar | 1 | |||
| 64 | Maximizing Language Development in Children With Hearing Loss | 2013 | USA | 1 | |||
| 65 | Mother and Child Education Program in Palestinian Refugee Camps | 2014 | Lebanon | 1 | |||
| 66 | Early Intervention and Autism: Transformation From Research to Practice Through a Competency Based Model | 2017 | Sweden | 1 | |||
| 67 | Mindfulness Training and Parent-coaching Interventions for Autism Spectrum Disorder | 2015 | USA | 1 | |||
| 68 | Impact of an Intervention Program on Parenting Stress After Preterm Birth | 2006 | France | 1 | |||
| 69 | Efficacy Trial of the Kids in Transition to School (KITS) Program for Children With Developmental Disabilities and Behavioral Problems | 2008 | USA | 1 | |||
| 70 | Social-emotional Under 4’s Screening & Intervention S.U.S.I. | 2016 | USA | 1 | |||
| 71 | H3: Healthy Minds, Healthy Children, Healthy Chicago Project Evaluation | 2014 | UK | 1 | |||
| 72 | Reproducibility Inter-session of the Measurement Elastography of the Passive Stiffness of Medial Beams of Gastrocnemius Muscle of the Hemiplegic Cerebral Child | 2017 | France | 1 | |||
| 73 | Transition to Scale of Nutrition and Psychosocial Stimulation Program for Malnourished Children | 2014 | Bangladesh | 1 | |||
| 74 | Electronic Patient-reported Outcomes (e-PROs) in Early Intervention | 2016 | USA | 1 | |||
| 75 | Iron Deficiency Anemia and Psychosocial Stimulation | 2007 | Bangladesh | 1 | |||
| 76 | Omega Tots: A Randomized, Controlled Trial of Long-chain Polyunsaturated Fatty Acid Supplementation of Toddler Diets and Developmental Outcomes | 2012 | USA | 1 | |||
| 77 | Zinc, Iron, Vitamin A and Psychosocial Care for Child Growth and Development | 1998 | Indonesia | 1 | |||
| 78 | Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11 | 2002 | USA | 1 | |||
| 79 | The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas | 2014 | USA | 1 | |||
| 80 | Comparing Parent-Implemented Interventions for Toddlers With Autism Spectrum Disorders | 2007 | USA | 1 | |||
| 81 | Strengthening Families and Reducing Risk Thru Developmental and Legal Collaboration | 2011 | USA | 1 | |||
| 82 | Social Cognitive Development in Young Children With Autism | 2012 | USA | 1 | |||
| 83 | Evaluation of the Healthy Families Alaska Program | 1999 | USA | 1 | |||
| 84 | Initial Efficacy Study of Supporting Play, Exploration, & Early Development Intervention | 2011 | USA | 1 | |||
| 85 | Healthy Habits, Happy Homes: An Intervention to Improve Household Routines for Obesity Prevention | 2011 | USA | 1 | |||
| 86 | Age 12 Follow-up of Early Preventive Intervention (Memphis) | 2003 | USA | 1 | |||
| 87 | Project ASPIRE Efficacy Pilot: Achieving Superior Parental Involvement for Rehabilitative Excellence | 2009 | USA | 1 | |||
| 88 | Interventions for Communication in Autism Network | 2012 | USA | 1 | |||
| 89 | The Effects of a Parental Intervention on Electronic Media Exposure and Sleep Patterns in Adolescents | 2011 | Israel | 1 | |||
| 90 | A Trial of Sertraline in Young Children With Autism Spectrum Disorder | 2015 | USA | 1 | |||
| 91 | A Randomized Controlled Trial of PCIT-ED for Preschool Depression | 2014 | USA | 1 | |||
| 92 | Psychomotor Therapy for Very Premature Infants | 2007 | France | 1 | |||
| 93 | A Website to Teach Children Safety With Dogs | 2015 | USA | 1 | |||
| 94 | Early Physical Therapy Intervention in Preterm Infants | 2017 | Spain | 1 | |||
| 95 | The Children in Action Feasibility Study | 2007 | USA | 1 | |||
| 96 | Development of Appetite Measuring Tool and Appetite Status of Stunted Children | 2016 | Bangladesh | 1 | |||
| 97 | Early Pharmacotherapy Aimed at Neuroplasticity in Autism: Safety and Efficacy | 2004 | USA | 1 | |||
| 98 | Study and Development of Application Models of “Therapeutic Education to the Patient” (TEP) in Asthmatic Children | 2007 | Italy | 1 | |||
| 99 | Development and Effectiveness of Home-based Programs for Preschool Children With Developmental Delay | 2017 | USA | 1 | |||
| 100 | Digital Literacy Promotion | 2016 | Bangladesh | 1 | |||
| TOTAL | 4 | 21 | 25 | 50 |