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. 2021 Mar 23;21:119–133. doi: 10.1016/j.omto.2021.03.012

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© 2021 The Authors.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Let-7d-5p targeted HMGA1 in CRC cells

(A) Complementary binding sites between let-7d-5p and HMGA1 mRNA. (B) Relative luciferase activity of HMGA1-WT and HMGA1-MUT in transfected cells. (C and D) Relative HMGA1 mRNA and protein levels in transfected cells. (E and F) Relative circBANP, let-7d-5p, and HMGA1 mRNA levels in transfected cells following Ago2 or immunoglobulin G (IgG) immunoprecipitation. (G) Relative HMGA1 mRNA levels in CRC tissues. (H) Kaplan-Meier survival curve in patients with high or low HMGA1 level. (I) Correlation between HMGA1 mRNA level and let-7d-5p level in CRC tissues. Data were presented as means ± SD. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.