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. 2021 Apr 28;97:107694. doi: 10.1016/j.intimp.2021.107694

Table 3.

Registered clinical trials on the Clinicaltrials.gov administrating MSCs to treat COVID-19.

SC source Dose and Route of administration No. Phase Status Location Study design Identifier
BM-MSCs
BM-MSCs A single dose of 1–2 × 10 6 cells/kg, IV 9 1 Recruiting Sweden Interventional, Single Group Assignment, Open-Label Masking NCT04447833
BM-MSCs Three times of 1.5–3 × 106 cells/kg, IV 20 1|2 Recruiting Belgium Single Group Assignment, Open Label NCT04445454
BM-MSCs Two doses of 2 × 106 cells/kg, IV 20 2 Recruiting Pakistan Randomized, Parallel Assignment, Open Label NCT04444271
BM-MSCs Gp 1: Three doses of 25 × 10 6 cells/kg, IV
Gp 2: Three doses of 50 × 10 6 cells/kg, IV
Gp 3: Three doses of 90 × 10 6 cells/kg, IV		 9 1 Recruiting Canada Non-Randomize, Interventional, Sequential Assignment, Open Label NCT04400032
BM-MSCs NA 45 1 Recruiting USA Randomized, Parallel Assignment, Quadruple Masking NCT04397796
BM-MSCs NA 10 NA Not yet recruiting UK Observational, Case-Only, Prospective NCT04397471
BM-MSCs NA 40 2 Not yet recruiting Germany Randomized, Parallel Assignment, Open Label NCT04377334
BM-MSCs Two doses of 2 × 106 cells/kg, IV 223 3 Active, not recruiting USA Randomized, Parallel Assignment, Triple Masking NCT04371393
BM-MSCs A single dose of 1 × 106 cells/kg, IV 20 1|2 Not yet recruiting China Randomized, Parallel Assignment, Single Masking NCT04346368
BM-MSCs Four doses of 1 × 108 cells/kg, IV 30 1 Not yet recruiting USA Single group, Parallel Assignment, Open Label NCT04345601
BM-MSCs A single dose of 1 × 106 cells/kg 10 1 Not yet recruiting Brazil Single Group Assignment-Open Label NCT04467047
BM-MSCs A single dose of 2 × 106 cells/kg 600 NA Completed Pakistan Non-Randomized, Factorial Assignment, Open Label NCT04492501
BM-MSCs Two doses, IV 40 2 Recruiting USA Randomized, Parallel Assignment, Quadruple Masking, double-blind NCT04780685
UC-MSCs
UC-MSCs A single dose, IV 40 1 Completed USA Randomized, Single Group Assignment, Triple Masking NCT04573270
UC-MSCs Two doses of 10 × 107 cells, IV 60 1|2 Recruiting USA Randomized, Parallel Assignment, Triple Masking NCT04494386
UC-MSCs Two doses of 10 × 107 cells, IV 21 1|2 Not yet recruiting USA Randomized, Parallel Assignment, Double Masking NCT04490486
UC-MSCs A single dose of 1 × 106 cells/kg, IV 40 1 Recruiting Indonesia Randomized, Interventional, Parallel Assignment, Triple Masking NCT04457609
UC-MSCs Single-dose of 0.5, 1, 1.5 × 106 cells/kg, IV 39 1|2 Not yet recruiting USA Non-Randomized, Sequential Assignment, Open Label NCT04452097
UC-MSCs 5 × 105 cells/kg, IV 20 2 Recruiting Pakistan Randomized, Parallel Assignment, Open Label NCT04437823
UC-MSCs A single dose of 1 × 106 cells/kg, IV 30 2 Not yet recruiting Colombia Randomized, Parallel Assignment, Triple Masking NCT04429763
UC-MSCs 1 × 106 cells/kg, IV 10 2 Recruiting Mexico Allocation: Non-Randomized, Parallel Assignment, Open Label NCT04416139
UC-MSCs Three doses of 1 × 106 cells/kg 30 1|2 Recruiting USA Randomized, Single Group Assignment, Quadruple Masking NCT04399889
UC-MSCs A single dose of 1 × 106 cells/kg 70 1|2 Not yet recruiting USA Randomized, Parallel Assignment, Double Masking NCT04398303
UC-MSCs Three doses 3 × 10 6 cells, IV 30 1|2 Recruiting Turkey Randomized, Parallel Assignment, Quadruple Masking NCT04392778
UC-MSCs Two doses of 50 × 106 cells, IV 40 1|2 Not yet recruiting Colombia Randomized, Parallel Assignment, Quadruple Masking NCT04390152
UC-MSCs Four doses of 1 × 106 cells, IV 60 1 Active, not recruiting China Randomized, Parallel Assignment, Open Label NCT04371601
UC-MSCs NA 106 2 Recruiting Spain Randomized, Parallel Assignment, open-label NCT04366271
UC-MSCs Two doses of 100 × 106 cells, IV 24 1|2 Completed USA Randomized, Parallel Assignment, Triple Masking NCT04355728
UC-MSCs Three doses of 4 × 107 cells, IV 100 2 Completed China Randomized, Parallel Assignment, Quadruple Masking NCT04288102
UC-MSCs Four doses of 5 × 106 cells, IV 48 NA Not yet recruiting China Randomized, Parallel Assignment, Open Label NCT04273646
UC-MSCs Four doses of 9.9 × 107 cells, IV 16 2 Recruiting China Non-randomized, Single Group Assignment, Open Label NCT04269525
UC-MSCs Three doses of 3 × 107 cells, IV 20 1 Recruiting China Non-Randomized, Parallel Assignment, Open Label NCT04252118
UC-MSCs Two doses of 1 × 106 cells/kg, IV 30 1|2 Recruiting China Randomized, Parallel Assignment, Triple Masking NCT04339660
UC-MSCs A single dose of 4 × 108 cells, IV 75 1|2 Recruiting UK Randomized, Parallel Assignment, Quadruple Masking NCT03042143
UCWJ-MSCs Three doses of 1 × 106 cells, IV 47 1|2 Active, not recruiting France Randomized, Interventional, Parallel Assignment, Triple Masking NCT04333368
CB-MSCs NA, IV 70 1 Recruiting USA Randomized, Parallel Assignment, Open Label NCT04565665
PLX-PAD High and low doses, IV 140 2 Recruiting USA Randomized, Parallel Assignment, Quadruple Masking NCT04389450
PLX-PAD A single dose of 3 × 108 cells, IV 40 2 Recruiting Israel Randomized, Parallel Assignment, Open Label NCT04614025
Placenta-MSCs Three doses of 1 × 106 cells/kg, IV 30 1|2 Recruiting Ukraine Non-Randomized, Parallel Assignment, Open Label NCT04461925
Embryonic SCs 1 × 106 cells 9 1|2 Recruiting China Interventional, Open Label NCT04331613
WJ-MSCs
WJ-MSCs Three doses of 106 cells/kg 30 2 Not yet recruiting Spain Randomized, Single Group Assignment, Quadruple Masking NCT04625738
WJ-MSCs A single dose of 10 × 107 cells, IV 9 1 Active, not recruiting Mexico Single Group Assignment, Open Label NCT04456361
WJ-MSCs 106 cells, IV 30 1|2 Recruiting Spain Randomized, Parallel Assignment, Quadruple Masking NCT04390139
WJ-MSCs Four doses of 1 × 106 cells/kg, IV 5 1 Recruiting Jordan Single Group Assignment, Open Label NCT04313322
AD-MSCs
AD-MSCs A single dose of 1 × 106 cells/kg, IV 20 1 Recruiting Mexico Randomized, Parallel Assignment, Open Label NCT04611256
AD-MSCs NA 10 1|2 Not yet recruiting Korea Single Group Assignment, Open Label NCT04527224
AD-MSCs four times 10 × 107 cells/time 6 1 Not yet recruiting Japan Single Group Assignment, Open Label NCT04522986
AD-MSCs NA, IV 20 1 Recruiting USA Interventional, Single Group Assignment, Open Label NCT04486001
AD-MSCs Five doses of 1 × 108 cells 20 2 Recruiting USA Interventional, Single Group Assignment, Open Label NCT04349631
AD-MSCs Three doses of 20 × 107 cells, IV 200 2 Not yet recruiting USA Randomized, Parallel Assignment, Double Masking NCT04428801
AD-MSCs Five doses of 2 × 108, 1 × 108, 5 × 107 cells, IV 100 2 Enrolling by invitation USA Randomized, Parallel Assignment, Quadruple Masking NCT04348435
AD-MSCs Two doses of 8 × 10 7 cells, IV 26 1|2 Active, not recruiting Spain Randomized, Parallel Assignment, Open Label NCT04366323
AD-MSCs 5 × 10 7 cells/kg, IV 20 1 Not yet recruiting USA Non-Randomized, Sequential Assignment, Open Label NCT04352803
AD-MSCs Four doses of 1 × 108 cells, IV 100 2 Active, not recruiting USA Randomized, Parallel Assignment, Quadruple Masking NCT04362189
AD-MSCs Two doses of 1.5 × 106 cells/kg 100 2 Not yet recruiting Spain Randomized, Parallel Assignment-Quadruple Masking-Multi center NCT04348461
AD-MSCs 1–1.5 × 106 cells/kg 100 2 Not yet recruiting USA Randomized, Parallel Assignment, Double Masking NCT04728698
AD-MSCs Five doses, IV 56 2 Active, not recruiting USA Interventional, Single Group Assignment, Open Label NCT04349631
Other Sources
DP-MSCs Three doses of 3 × 107, IV 20 1|2 Recruiting China Randomized, Interventional. Parallel Assignment, Triple Masking NCT04336254
DP-MSCs Three doses of 1 × 106 cells, IV 24 1 Not yet recruiting China Interventional, Single Group Assignment, Open Label NCT04302519
LMSCs Three doses of 1 × 108 cells, IV 70 1 Recruiting USA Randomized, Parallel Assignment, Double Masking NCT04629105
Cymerus MSCs 2 million cells/kg, IV 24 1|2 Recruiting Australia Randomized, Parallel Assignment, Open Label NCT04537351
RNA-engineered NA 30 1|2 Recruiting USA Single Group Assignment, Open Label NCT04524962
Olfactory MSCs NA, IV 40 1|2 Enrolling by invitation Belarus Non-Randomized, Parallel Assignment, Open Label NCT04382547
SCE A single dose, IV 20 2 Not yet recruiting China Randomized, Parallel Assignment, Single Masking NCT04299152
NHPBSCs 1 × 106 cells, IV 146 1|2 Completed UAE Randomized, Open-Label NCT04473170
Progenitor NA, IV 400 2|3 Recruiting USA Randomized, Parallel Assignment, Quadruple Masking, NCT04367077
Undefined-MSCs
MSCs Three doses of 300 × 10, IV 30 2 Recruiting USA Randomized, placebo-controlled-parallel assignment, Triple Masking NCT04466098
MSCs 250 to 750 million 22 1|2 Recruiting USA Randomized, Interventional, Parallel Assignment, Quadruple Masking NCT04445220
MSCs A single dose of 1 × 10 6 cells/kg 20 2 Recruiting Spain Randomized, Parallel Assignment, Double Masking NCT04615429
MSCs A single dose of 2.5,5 or 10 × 107 cells, IV 20 1 Recruiting Brazil Randomized, Parallel Assignment, Open Label NCT04525378
MSCs Four doses of 2 × 10 7 cells, IV 90 2 Not yet recruiting Brazil Interventional, Parallel Assignment, Quadruple Masking NCT04315987
MSCs Three doses of 1 × 10 6 cells/kg 21 NA Completed Turkey Randomized, Parallel Assignment, Open Label NCT04713878
MSCs A single dose of 1 × 10 6 cells/kg, IV 24 2 Recruiting Spain Randomized, Parallel Assignment, Triple Masking NCT04361942
DW-MSCs Low dose gp: 5 × 107cells, IV
High dose gp: 1 × 108 cells, IV		 9 1 Recruiting Indonesia Randomized, Interventional, Parallel Assignment, Quadruple Masking NCT04535856

MSC: Mesenchymal stem cell; BM-MSC: Bone marrow-MSC; UC-MSC: Umbilical cord-MSC; CM: Conditioned media; AD-MSCs: Adipocyte derived MSCs; WJ-MSCs: Warton jelly-MSC; CB-MSC: Cord blood-MSC; IMRC: immunity- and matrix-regulatory cell; DP-MSCs: Dental pulp MSCs; LMSCs: Longeveron MSCs; SCE: Stem cell educator; NHPBSC: Non-hematopoietic peripheral blood stem cells; gp: Group; IV: Intravenous; NA: Not available.