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. 2021 Apr 27;4:506. doi: 10.1038/s42003-021-02024-1

Fig. 5. Validation of previously unknown fusion gene isoforms identified in colon cancers through LoopSeq sequencing.

Fig. 5

A STAMBPL1-FAS fusion. Top: diagram of mini genomes of STAMBPL1 and FAS. Direction of transcription and distance between the two genes are indicated. Middle: mRNA represented by exons from each gene. Bottom: diagram of functional protein domains of STAMBPL1 and FAS. B ZNF124-SMYD3 fusion. Top: diagram of minigenomes of ZNF124 and SMYD3. Direction of transcription and distance between the two genes are indicated. Middle: mRNA represented by exons from each gene. Bottom: diagram of functional protein domains of ZNF124 and SMYD3. C PTPRK-ECHCD1 fusion. Top: diagram of minigenomes of PTPRK and ECHCD1. Direction of transcription and distance between the two genes are indicated. Middle: mRNA represented by exons from each gene. Bottom: diagram of functional protein domains of PTPRK and ECHCD1. D VAPB-GNAS fusion. Top: diagram of minigenomes of VAPB and GNAS. Direction of transcription and distance between the two genes are indicated. Middle: mRNA represented by exons from each gene. Bottom: diagram of functional protein domains of VAPB and GNAS.