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. 2021 Apr 27;11:9091. doi: 10.1038/s41598-021-88683-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The requirement for HER3 in HER2-amplified tumorigenic growth. (A) HER3 expression was knocked down by shRNA targeting in the indicated HER2-amplified cancer cell lines. Control cells express a scrambled shRNA sequence. (B–D) NSG mice were inoculated subcutaneously with these engineered tumor cells and their in vivo growth rates monitored over the indicated time span. The total sample sizes were n = 19 (OE-19), n = 19 (H2170), and n = 20 (N87) and the errors bars indicate the standard error of the mean. (E) Tumors from these mice were harvested at the time of termination of the study and lysates immunoblotted as indicated to confirm the persistent knockdown of HER3 in vivo.