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. 2021 Apr 27;11:9080. doi: 10.1038/s41598-021-88648-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) CT scan of liver metastases from the patient before (baseline) and after (post-treatment) systemic targeted therapy and chemotherapy. Arrows indicate locations of liver metastases. (B) Counts for mRNA of MHC class I, NK cell ligands, PD-1, PD-L1, and PD-L2 from tumors at baseline (white bar) and after treatment (black bar) by NanoString. Grey line indicates the fold change shown as percentage. (C) IHC staining from the tumor tissue before (baseline) and after (post-treatment) systemic targeted therapy and chemotherapy. DAPI staining indicated the nucleus. Pan-CK staining indicated tumor cells. All immunofluorescence signals were within one image. (D) Computerized scanning of IHC staining from the tumor tissue before (baseline) and after (post-treatment) systemic targeted therapy and chemotherapy. The tumor parts were defined as pan-CK positive and DAPI-positive cells. The nontumor parts were defined as pan-CK negative and DAPI-positive cells. The whole field was then counted with a computer. (E) Percentage of marker expression for MHC class I, from tumor at baseline (blue bar) and after treatment (red bar).