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. 2021 Apr 27;11:9022. doi: 10.1038/s41598-021-88430-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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ApoE^-/- mice immunized with native p210-PADRE develop p210-specific IgG1 antibodies and less atherosclerosis. ApoE^-/- mice were immunized with native p210-PADRE or PADRE peptide. IgG1 (a, c, e) and IgG2c (b, d, f) antibodies against p210 (a, b), p210-PADRE (c, d), or PADRE (e, f) (plasma dilution 1:1000) from immunized mice were analyzed in ELISA. Atherosclerotic plaque formation was analyzed in the aortic arch (g) and in subvalvular plaques (h). Macrophage (i), collagen (j), lipid (k), and MDA-LDL (l) content were analyzed in subvalvular plaques. Data are depicted as individual mice, with bars indicating median (IQR) (a–f) or mean ± SD (g–k). *p < 0.05, **p < 0.01, ***p < 0.001; Mann–Whitney test (a–f) or Unpaired t-test (g–l).