Figure 1.

Glomerular lesion in STZ-induced diabetic mice. STZ or Vehicle control (Ve) solution was injected into the intraperitoneal cavity of 6–8 week-old male octn1 KO and WT mice. Blood glucose levels (a) and body weight (b) of the octn1 KO and WT mice (circle: WT-Ve, triangle: KO-Ve, filled circle: WT-STZ, filled triangle: KO-STZ) were shown. OCTN1 mRNA expression was only detected in the WT mice (c). Glomerular images by PAS staining were shown in panel (d) before and after STZ injection. F4/80-positive (e) and CD3-positive cells (f) were faintly detected in the glomeruli. Urinary levels of albumin in the octn1 KO and WT mice was almost no increase throughout the observation period (g). KO, octn1 KO mice; WT, wild-type mice; STZ, STZ injected mice; Ve, vehicle control.*P < 0.05 for each control. The scale bar represents 100 μm.