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. 2021 Apr 27;11:9093. doi: 10.1038/s41598-021-88724-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of oxidative stress and interstitial fibrosis in STZ-induced diabetic mice. Urinary 8-OHdG levels were detected in the diabetic mice (a). Interstitial fibrosis was detected by Azan staining (b) and Sirus red staining (d), and the fibrotic areas were quantified (c,e). The amount of hydroxyproline in the mice kidneys was measured (f). Interstitial F4/80-positive cells were detected by immunohistochemistry (g) and their positive area was evaluated (h). The number of CD3-positive cells was also detected by immunohistochemistry and counted (i). KO, octn1 KO mice; WT, wild type mice; STZ, STZ injected mice; Ve; vehicle control. The scale bar represents 100 μm.