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. 2021 Apr 27;11:9093. doi: 10.1038/s41598-021-88724-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comprehensive gene analysis in the kidney, and cluster and pathway analysis. As a result of the cluster analysis, gene expression of the 4 groups (WT-Ve, KO-Ve, WT-STZ, KO-STZ) was seen to be significantly different (a). Upregulated (b) and downregulated (c) pathways were listed to compare the WT-STZ and KO-STZ groups. Upregulated (d) and downregulated (e) pathways were listed to compare the WT-Ve and WT-STZ groups. Lists of high Z-scored molecules included in the cytoskeleton- and cell adhesion-related pathways were shown (f). KO, octn1 KO mice; WT, wild type mice; STZ, STZ injected mice; Ve, vehicle control.