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. 2021 Apr 27;11:9124. doi: 10.1038/s41598-021-88589-7

Table 2.

Changes in TBUT, Schirmer’s I test score, ocular surface disease index (OSDI), and lipid layer thickness (LLT) in the DQS group and the HA group.

Preoperative Postoperative 3 weeks Postoperative 7 weeks Postoperative 15 weeks pa pb pre vs 3 weeks pc pre vs 7 weeks pd pre vs 15 weeks p value*
TBUT
DQS 13.17 ± 2.26 13.64 ± 1.68 13.93 ± 1.61 14.57 ± 0.96 0.023 0.734 0.351 0.014 0.011
HA 12.37 ± 1.97 12.67 ± 2.25 13.16 ± 1.83 13.41 ± 1.56 0.235 0.953 0.486 0.245
Schirmer’s I test score
DQS 12.74 ± 2.56 13.23 ± 2.93 13.22 ± 3.11 13.44 ± 3.12 0.908 0.931 0.931 0.931 0.508
HA 12.04 ± 2.51 12.33 ± 2.49 13.12 ± 2.84 13.00 ± 3.03 0.457 0.983 0.519 0.619
OSDI
DQS 15.24 ± 8.59 8.28 ± 5.92 7.80 ± 5.81 6.36 ± 5.27  < 0.001 0.002 0.001  < 0.001 0.009
HA 17.94 ± 7.78 12.74 ± 7.77 13.16 ± 7.54 12.79 ± 7.97 0.119 0.174 0.237 0.181
LLT
DQS 87.78 ± 13.55 92.57 ± 10.79 92.42 ± 10.80 95.96 ± 7.22 0.010 0.321 0.348 0.004  < 0.001
HA 79.21 ± 18.33 77.87 ± 20.41 79.67 ± 22.59 84.96 ± 15.74 0.606 0.995 1.000 0.735

Statistically significant p values are marked in bold (p < 0.05).

TBUT tear break up time, OSDI ocular surface disease index, LLT lipid layer thickness.

*p value < 0.05 by repeated-measures analysis of variance.

ap value < 0.05 one-way analysis followed by post-hoc Tukey analysis.

bBetween preoperative visit and postoperative 3 weeks.

cBetween preoperative visit and postoperative 7 weeks.

dBetween preoperative visit and postoperative 15 weeks.