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. 2021 Apr 27;11:9052. doi: 10.1038/s41598-021-88690-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased blood supply in the inner retina: severe in ND, much milder in HF and LF groups. Time series of retinal fundus fluorescein angiography (FFA) images at different time points after fluorescein injection show significantly delayed retinal vessel filling and marked capillary non-perfusion in the ND group, whereas the HF group is similar to the control (CON) group, at 5wpi. Three animals of each group were imaged.