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. 2021 Apr 14;13:611891. doi: 10.3389/fnagi.2021.611891

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Copyright © 2021 Li, Zhang, Che, Zhang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolution of susceptibility values with age in the caudate nucleus, putamen, globus pallidus, red nucleus, substantia nigra, and dentate nucleus. These images were from a 64-year-old female non-smoker without hypertension and type 2 diabetes mellitus (T2DM). The upper row (A–C) shows quantitative susceptibility mapping (QSM) images acquired in 2011, and the bottom row (D–F) shows QSM images acquired in 2019. Susceptibility values of the gray matter nuclei increased significantly over time.