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. 2021 Apr 14;12:632618. doi: 10.3389/fneur.2021.632618

Table 4.

Percentage of the sample that meets criteria for each traumatic encephalopathy syndrome feature at moderate severity or greater, stratified by subgroups.

Core Clinical Features Supportive Features
n Cognitive Behavioral Mood Impulsivity Anxiety Apathy Paranoia Headache Motor signs
Total sample 409 19.8 11.0 26.4 6.4 31.3 19.3 7.1 34.2 9.8
Non-contact sports or no sports in high school 214 18.7 8.9 25.7 7.5 32.7 17.8 8.4 30.8 8.9
Football in high school 125 23.2 16.0 28.0 7.2 29.6 20.0 8.0 40.8 12.0
Contact sports in high school (not football) 70 17.1 8.6 25.7 1.4 30.0 22.9 1.4 32.9 8.6
0–3 Concussions 366 17.2 7.7 23.8 5.7 29.0 16.3 6.3 30.3 7.9
4+ Concussions 43 41.9 39.5 48.8 11.6 51.2 41.9 14.0 69.8 25.6
0–5 Years contact sports 369 19.5 10.8 27.4 7.0 32.2 19.2 7.3 33.3 10.0
6+ Years contact sports 40 22.5 12.5 17.5 0.0 22.5 20.0 5.0 42.5 7.5
6+ Years contact sports (with 2+ in college) 22 27.3 9.1 18.2 0.0 13.6 18.2 4.5 45.5 9.1
Did not meet neurotrauma exposure criterion 344 16.3 7.8 24.1 6.1 30.2 16.6 6.4 29.4 8.1
Met neurotrauma exposure criterion 65 35.4 27.7 38.5 7.7 36.9 33.8 10.8 60.0 18.5
Medication for anxiety 115 29.6 20.0 47.0 9.6 60.0 32.2 14.8 51.3 16.5
Medication for depression 117 36.8 23.1 52.1 12.0 59.0 36.8 13.7 42.7 15.4
Medication for ADHD 37 45.9 21.6 32.4 10.8 51.4 27.0 16.2 40.5 8.1
Of those with 0 concussions and No Contact Sports… 126 15.1 7.9 20.6 7.9 29.4 11.1 8.7 24.6 4.8
No/Minimal pain in the past year 42 7.1 2.4 7.1 7.1 14.3 2.4 2.4 4.8 0.0
Mild or worse pain in the past year 84 19.0 10.7 27.4 8.3 36.9 15.5 11.9 34.5 7.1
No/Minimal sleep issues in the past year 55 7.3 1.8 5.5 7.3 10.9 1.8 3.6 10.9 1.8
Mild or worse sleep issues in the past year 71 21.1 12.7 32.4 8.5 43.7 18.3 12.7 35.2 7.0
Mild or worse sleep issues and mild or worse pain issues 61 23.0 14.8 34.4 9.8 42.6 19.7 14.8 41.0 8.2
I have felt depressed = Never or Rarely 75 8.0 4.0 0.0 6.7 10.7 4.0 4.0 20.0 1.3
I have felt depressed = Sometimes, Often, or Always 51 25.5 13.7 51.0 9.8 56.9 21.6 15.7 31.4 9.8

Supportive criteria for suicidality, documented decline, and delayed onset were not assessed. Regarding medications, participants reported a past history of being recommended or prescribed medications for anxiety, depression, or ADHD. The neurotrauma exposure criterion was operationally defined as a personal history of 4 or more concussions, or 6 or more years playing contact sports with 2 or more years at the college level or higher, or both.