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. 2021 Apr 14;12:653081. doi: 10.3389/fimmu.2021.653081

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Copyright © 2021 Hagelstein, Lutz, Schmidt, Heitmann, Malenke, Zhou, Clar, Kopp, Jung, Salih, Märklin and Hinterleitner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanism of action of NKG2D-CD16/CD3 fusion proteins. Schematic illustration of BFP consisting of the extracellular domain of the NKG2D receptor fused to Fab-fragments directed against CD3 (NKG2D-CD3) or CD16 (NKG2D-CD16). Binding of NKG2D to NKG2DL (MICA/B, ULBP1-6) leads to activation of T cells and NK cells via anti-CD3 and anti-CD16 Fab-fragments and subsequent lysis of tumor cells. The graphic was created with BioRender software (BioRender.com, Toronto, Canada).