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. 2021 Apr 14;9:649277. doi: 10.3389/fcell.2021.649277

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Copyright © 2021 Wang, Wang, Kong, Shi, Wang, Chai, Xu and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADM2 regulates the NF-κB/β-catenin and AKT/β-catenin signaling in BMSCs. (A) Western blot of AKT, p-AKT, p65, p-p65, β-catenin, and p-β-catenin in BMSCs treated with OIM, OIM + ADM2, OIM + ADM2 + TNF-α, OIM + ADM2 + MK2206, and OIM + ADM2 + TNF-α + MK2206. (B) Quantitative analysis in the expression of β-catenin and phosphorylated levels of AKT, p65, and β-catenin. (C) Representative immunocytochemistry images showing the expression and distribution of β-catenin in BMSCs from each group. Scale bar: 100 μm. (D) Quantitative analysis of the nuclear translocation of β-catenin. The data were confirmed by one-way analysis of variance (ANOVA) followed by Tukey’s post hoc test from three independently repeated tests and are presented as the means ± SD. ^∗P < 0.05, ^∗∗P < 0.01. MFI, mean fluorescence intensity.