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. 2021 Apr 14;9:649277. doi: 10.3389/fcell.2021.649277

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Copyright © 2021 Wang, Wang, Kong, Shi, Wang, Chai, Xu and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADM2 administration accelerates bone consolidation during distraction osteogenesis in rats. (A) Mechanical properties, including E-modulus, ultimate load, and energy to failure of distraction regenerates in control (n = 6) and ADM2 (n = 6) groups. The values were normalized to the corresponding contralateral normal tibias. (B) Representative X-rays of distraction regenerates at various time points. (C,D) Representative 3D and longitudinal images (C) and quantitative analysis (D) of micro-CT data, including bone mineral density (BMD) and bone volume/tissue volume (BV/TV), of the tibial distraction area after 2 (n = 6) and 4 (n = 6) weeks of consolidation and treatment. The data were confirmed by Student’s t-test between control group and ADM2 group. *P < 0.05, **P < 0.01.