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. 2021 Apr 14;12:665476. doi: 10.3389/fphys.2021.665476

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Copyright © 2021 Martini, Ripperger, Chavan, Stumpe, Netzahualcoyotzi, Pellerin and Albrecht.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mice heterozygous for Mct1 display reduced FAA but have a normal temperature profile. (A) Examples of wheel-running actograms of Mct1^+/+ (left panel) and Mct1^+/– mice (right panel) under ad libitum (AL) and daytime-restricted feeding (RF) conditions. The vertical line at ZT4 indicates the time of food access. (B) Quantified wheel-running activity plots under AL (left panel) and the last week of RF (right panel) conditions. Food anticipatory activity (FAA) under RF is significantly reduced in Mct1^+/– (blue) and normalized Mct1^+/– (red) compared to Mct1^+/+ mice (black). Activity was normalized to dark phase activity of controls (n = 13–15, 2-way ANOVA, ****p = 4.89 × 10^–4, F = 13.22). (C) Quantified general activity plots under AL (left panel) and RF (right panel) conditions. FAA under RF is significantly reduced in Mct1^+/– (blue) compared to Mct1^+/+ mice (black) (n = 8–9, 2-way ANOVA, *p = 0.01, F = 7.02). (D) Internal body temperature profiles under AL (left panel) and RF (right panel) conditions. No differences were observed between the genotypes under both AL and RF conditions (n = 8–9, 2-way ANOVA, p > 0.05). Error bars represent the standard error of mean.