Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 14;12:651357. doi: 10.3389/fimmu.2021.651357

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Akiyama, Suzuki, Yoshimoto, Yasuoka, Kaneko and Takeuchi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The increase of TIGIT ⁺ Tfh cells in IgG4-RD. The proportion of TIGIT⁺ CD4⁺ T cells (A), TIGIT⁺ Tfh cells (B, C), TIGIT^- Th cells (D), the ratio of TIGIT⁺ Tfh to TIGIT^- Th cells (E), and the ratio of TIGIT⁺ Tfh to CD4⁺ T cells (F) were examined in blood from patients with untreated, active IgG4-RD (n=23) or healthy individuals (n=21). The proportion of TIGIT⁺ Tfh1 (H), TIGIT⁺ Tfh2 (G, I), and TIGIT⁺ Tfh17 (J) cells was analyzed and compared. (A, C–F, H–J) unpaired t test. ****p<0.0001, **p<0.01, ns p>0.05.