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. 2021 Apr 14;12:651656. doi: 10.3389/fimmu.2021.651656

Figure 4.

Figure 4

Metabolic rewiring correlate with the differentiation, immunoglobin secretion and survival of PCs and for the differentiation of memory B cells in COVID-19 patients. (A) The selected functional changes in PCs and memory B cells in COVID-19 patients (Student’s t-test; *P < 0.05; **P < 0.01; ****P < 0.0001); H, healthy control; M, patients with mild COVID-19; S, patients with severe COVID-19. (B) The Pearson correlations between the scores of B cell function and metabolic processes and signaling pathways in PCs (left panel) and memory B cells (right panel) of COVID-19 patients. “ρ” indicates the Pearson correlation coefficient; only dots representing correlations with |ρ| > 0.15 and P < 0.05 are shown. (C, D) Coexpression modules of DEGs in PCs and memory B cells in COVID-19 patients. The metabolism-related genes are marked. The coexpression modules in patients with mild and severe disease are shown in the lower triangle and upper triangle, respectively. “ρ” indicates the Pearson correlation coefficient. (E) The delineation of metabolism-immune response crosstalk in PCs and memory B cells in COVID-19 patients according to the DEGs and the KEGG pathways in which they participated. The S-specific DEGs are shown in red. The M-specific DEGs are shown in blue. The DEGs in COVID-19 patients are shown in black.